. http://wiki.keithl.com/BillGates === Bill Gates Books === == How To Prevent the Next Pandemic == . copyright 2022, written earlier by large team .p006 [[ https://en.wikipedia.org/wiki/William_Foege | Bill Foege ]] CDC `977-`993 .p039 [[ https://en.wikipedia.org/wiki/MRNA_vaccine | Messenger RNA Vaccine, ]] 6 billion doses in 2021 .p046 need well funded global organization focused on pandemic prevention .p059 [[ https://champshealth.org/ | CHAMPS ]] Child Health And Mortality Protection Surveillance global network .p072 [[ https://scholar.google.com/citations?user=TPWwr18AAAAJ&hl=en | Michael Famulare ]] estimated 570 (80 to 1500 90% confidence) infected when first two patients identified .p074 2020 March 30 NYT [[ https://www.nytimes.com/2020/03/01/health/coronavirus-washington-spread.html | Coronavirus May Have Spread in U.S. for Weeks, Gene Sequencing Suggest ]] .p096 flu cases dropped 99% in 2020-21 compared to 2019-2020 .p100 contact tracing requires widespread testing, fast results, and contacting people quickly .p102 droplets larger than 5μm, aerosols smaller. Heavier droplets carry more virus, but fall to ground within feet .p103 COVID viruses electrically charged, attract lung substances that slow aerosol drying .p104 Social distancing works, nothing magical about six feet .p105 Masks 1910 [[ https://en.wikipedia.org/wiki/Wu_Lien-teh | Wu Lien-teh ]] Maylayan physician fighting [[ https://en.wikipedia.org/wiki/Pneumonic_plague | pneumonic plague ]] in Manchuria .p108 N mask straps around back of head, KN mask straps around ears (unless ears flap forward like mine) .p113 [[ https://en.wikipedia.org/wiki/Hydroxychloroquine | hydroxychloroquine ]] blocked COVID in monkeys, buy humans have different pathway .p114 [[ https://en.wikipedia.org/wiki/Cytokine_storm | cytokine storm ]], blood vessels leak fluid into organs and lungs, the overreaction causes low blood pressure, organ failure, and death .p115 [[ https://en.wikipedia.org/wiki/Convalescent_plasma | convalescent plasma ]] and [[ https://en.wikipedia.org/wiki/Remdesivir | remdesivir ]] not verty effectove .p116 [[ https://en.wikipedia.org/wiki/Monoclonal_antibody | monoclonal antibodies mAbs ]] .p116 [[ https://en.wikipedia.org/wiki/Sotrovimab | Sotrovimab ]] isolated from [[ https://en.wikipedia.org/wiki/SARS | SARS ]] and modified (not effective ahttps://www.nih.gov/gainst Omicron) .p117 [[ https://en.wikipedia.org/wiki/Merck_%26_Co. | Merck ]] [[https://en.wikipedia.org/wiki/Molnupiravir | molnupiravir ]] .p117 [[ https://en.wikipedia.org/wiki/Nirmatrelvir/ritonavir | Paxlovid ]] [[ https://en.wikipedia.org/wiki/Pfizer | Pfizer ]] .p139 vaccines, from disease identification to Vaccines to 50% global vaccination || Disease || Identified || Vaccine Available || 50% || || Whooping Cough || 1906 || 1948 || 1986 || || Polio || 1908 || 1955 || 1985 || || Measles || 1953(?) || 1963 || 1987 || || COVID || 2020 || 2021 || 2021 || .p146 [[ https://cleanroomtechnology.com/vaccine-manufacturing-facilities-and-cleanrooms-explained-176581 | vaccine factory ]] standards, temperature, airflow, wall corner curvature .p149 [[ https://en.wikipedia.org/wiki/COVAX | COVAX ]] .p157 We were good, but we were also lucky (SARS and MERS experience helped) .p160 [[ https://www.hptn.org/news-and-events/announcements/remembering-dr-stephaun-e-wallace | Stephaun Wallace ]] at [[ https://www.fredhutch.org/en.html | Fred Hutch ]] [[ https://www.seattletimes.com/life/seattle-medical-and-ballroom-community-mourns-loss-of-stephaun-e-wallace/ | died 2023 age 45 ]] .p165 "cookbook by [[ https://en.wikipedia.org/wiki/David_Chang | David Chang ]] analogy .p169 [[ https://www.who.int/ | WHO ]] [[ https://www.who.int/news-room/feature-stories/detail/vaccine-efficacy-effectiveness-and-protection | vaccine approval ]] .p196 Pentagon budget $700B/year, [[ https://www.nih.gov/ | NIH ]] $43B/year .p196 Bill Foege CDC successor [[ https://en.wikipedia.org/wiki/James_O._Mason | James Mason ]] 1983-89) closed down CDC bioterrorism program .p203 5 million child deaths per year, main focus of Gates Foundation .p222 [[ https://en.wikipedia.org/wiki/Transdermal_patch | Microneedle patches ]] .p223 Gates (and I) believe COVID was animal spillover, not lab leak .p225 Inattention: public health needs modernization, one state health department ran 20 year old software .p229 [[ https://en.wikipedia.org/wiki/Crimson_Contagion | Crimson Contagion ]] outbreak simulation .p246 [[ https://en.wikipedia.org/wiki/Telehealth | telehealth saves time ]]