== Paul Offit Books == === Do you Believe in Magic? === ==== The Sense and Nonsense of Alternative Medicine ==== === Paul A. Offit, M.D. - Multco Hollywood 615.5 o328d 2013 === .p1 42%/6000 hospitals offer some form of alternative therapies .p2 [[ https://en.wikipedia.org/wiki/Pfizer | Pfizer ]] acquired [[ https://www.pfizer.com/news/press-release/press-release-detail/pfizer_acquires_alacer_corp_a_leading_vitamin_supplements_company | Alacer ]] megavitamins (Emergen-C) .p3 M.D. wife [[ https://www.facebook.com/bonnie.fassoffit/ | Bonnie Fass-Offit ]] .p3 benign [[ https://www.hopkinsmedicine.org/health/conditions-and-diseases/blue-rubber-bleb-nevus-syndrome | Cutaneous Blue Ne .vus syndrome ]] mimics malignant melanoma, fools most dermatologists .p4 loss of cartilage beneath kneecap, surgery and 1 year recovery .p4 enlarged prostate, most men with prostate cat word5m | grep cancer die of something else first, while surgery is brutal .p5 Chiropractic manipulations can lead to injuries, acupuncture to infection, some megavitamins ''increase'' cancer risk ---- .'''p7 Introduction: Saving Joey Hofbauer''' .p7 [[ https://en.wikipedia.org/wiki/Amygdalin#Laetrile | laetrile ]] .p7 1977 Oct 5 neck lump in 7yo Joey Hofbauer, one swollen lymph gland .p8 Cancer of lymph glands, radiation and chemotherapy 95% chance of recovery .p11 laetrile "treatment" by psychologist [[ https://www.ratemds.com/doctor-ratings/8085/Dr-Michael+B.-Schachter-Suffern-NY.html/ | Michael B. Schachter ]] .p13 after six months of unconventional treatments, Joey had 17 swollen lymph glands, liver damage (megadose vitamin A), possible cyanide poisoning .p14 Laetrile [[ https://www.nytimes.com/1977/06/26/archives/inquiry-casts-doubt-on-laetrile-figures-credentials-of-four-who.html | Robert Bradford ]][[ https://en.wikipedia.org/wiki/John_Birch_Society | John Birch Society ]] .p15 [[ https://en.wikipedia.org/wiki/William_Donald_Kelley | William D. Kelley ]] Clinic Mexico [[ https://en.wikipedia.org/wiki/Steve_McQueen | Steve McQueen ]] (smoker, asbestos exposure in the marines) [[ https://en.wikipedia.org/wiki/Mesothelioma | pleural mesothelioma ]] died age 50 .p16 [[ https://www.nejm.org/doi/full/10.1056/NEJM197705192962013 | N Engl J Med 1977;296:1167-1168 ]] May 19 (not 26) 1977, Laetrilomania .p17 Judge rules alternatives adequate . p18 Joey dies 1980 July 10, !McQueen dies 1980 Nov 7 .p18 [[ https://en.wikipedia.org/wiki/Charles_Moertel | Charles Moertel ]] teams at Mayo, UCLA, Sloan-Kettering study 178 cancer patents on laetrile and high dose vitamins . no stabilization or improvement, median survival 4.8 moths, "... not justified", FDA bans laetrile in 1987 .p21 Fringe group [[ https://en.wikipedia.org/wiki/National_Health_Federation | National Health Federation ]] criticised by [[ https://en.wikipedia.org/wiki/American_Cancer_Society | American Cancer Society ]] and [[ https://en.wikipedia.org/wiki/Quackwatch | Quackwatch ]] ---- .'''p25 Ch 1 Recovering the Past: Mehmet Oz and His Superstars''' .p25 [[ https://en.wikipedia.org/wiki/Mehmet_Oz | Mehmet Oz ]] [[ https://en.wikipedia.org/wiki/The_Dr._Oz_Show | Dr. Oz Show ]] .p28 [[ https://en.wikipedia.org/wiki/Hippocrates | Hippocrates 400 BC ]] [[ https://en.wikipedia.org/wiki/Humorism | humors ]] [[ https://en.wikipedia.org/wiki/Acupuncture | acupuncture ]] [[ https://en.wikipedia.org/wiki/Qi | chi ]] .p29 [[ https://en.wikipedia.org/wiki/Benjamin_Rush | Benjamin Rush ]] [[ https://en.wikipedia.org/wiki/Bloodletting | bloodletting ]] hastened death of [[ https://en.wikipedia.org/wiki/George_Washington | George Washington ]] (with [[ https://en.wikipedia.org/wiki/Epiglottitis | Epiglottitis ]]) and [[ https://en.wikipedia.org/wiki/Benjamin_Franklin | Benjamin Franklin ]] .p30 [[ https://en.wikipedia.org/wiki/Edward_Jenner | Edward Jenner 1796 ]] [[ https://en.wikipedia.org/wiki/Smallpox_vaccine | smallpox vaccine ]] .p30-31 [[ https://en.wikipedia.org/wiki/John_Snow | John Snow cholera ]] [[ https://en.wikipedia.org/wiki/Robert_Koch | Robert Koch anthrax ]] [[ https://en.wikipedia.org/wiki/Alexander_Fleming | Alexander Fleming penicillin ]] [[ https://en.wikipedia.org/wiki/Oswald_Avery | Oswald Avery DNA ]] [[ https://en.wikipedia.org/wiki/James_Lind | James Lind scurvy ]] .p32 [[ https://en.wikipedia.org/wiki/Albert_Szent-Gy%C3%B6rgyi | Albert Szent-Györgyi vitamin C ]] .p32 Dr. Oz [[ https://en.wikipedia.org/wiki/Faith_healing | faith healer ]] [[ https://www.pathtofaith.com/ | Issam Nemeh ]] patient Cathy with worrisome lung CT, miraculously cured "cancer" (but no biopsy), probably infection .p33 [[ https://en.wikipedia.org/wiki/George_Bernard_Shaw | George Bernard Shaw ]] regards [[ https://en.wikipedia.org/wiki/Sanctuary_of_Our_Lady_of_Lourdes| Lourdes ]]: "All those canes, braces and crutches, and not a single glass eye, wooden leg, or toupee .p33 [[ https://reikiinmedicine.org/ | Pamela Miles ]] theraputic touch .p34 9yo [[ https://en.wikipedia.org/wiki/Emily_Rosa | Emily Rosa ]] debunks therapeutic touch, published in [[ https://jamanetwork.com/journals/jama/fullarticle/187390 | JAMA ]] .p35 [[ https://en.wikipedia.org/wiki/John_Edward | John Edward psychic ]] .p36 [[ https://en.wikipedia.org/wiki/James_Randi | James Randi ]] says strategies are [[ https://en.wikipedia.org/wiki/Hot_reading | hot reading ]] and [[ https://en.wikipedia.org/wiki/Cold_reading#:~:text=Cold%20reading%20is%20a%20set,the%20right%20direction%20or%20not. | cold reading ]] .p37 Oz's superstars of [[ https://en.wikipedia.org/wiki/Alternative_medicine | Alternative Medicine ]], [[ https://en.wikipedia.org/wiki/Andrew_Weil | Andrew Weil ]] and [[ https://en.wikipedia.org/wiki/Deepak_Chopra | Deepak Chopra ]] .p39 [[ https://en.wikipedia.org/wiki/Samuel_Hahnemann | Samuel Hahnemann ]] 1790 [[ https://en.wikipedia.org/wiki/Homeopathy | homeopathy ]] and [[ https://en.wikipedia.org/wiki/Daniel_David_Palmer | Daniel David Palmer ]] 1896 [[ https://en.wikipedia.org/wiki/Chiropractic | chiropractic manipulation ]] .p40 Oz offers instruction book for life, personalized ancient wisdom .p41 [[ https://en.wikipedia.org/wiki/2012_(film) | "2012" catastrophe movie (2009) ]] promotes "ancient wisdom" .p41 orthodox medicine constantly changing (learning) while alternative medicine same over hundreds of years .p42 mainland China only 18% rely in alternative medicines, acupuncture almost solely by the rural poor .p42 [[ https://www.betterworldbooks.com/product/detail/hippocratic-oaths-medicine-and-its-discontents-9781843541271 | Hippocratic Oaths : Medicine and Its Discontents ]] by Raymond Tallis .p42 [[ https://www.betterworldbooks.com/product/detail/snake-oil-and-other-preoccupations-0099428334 | Snake Oil And Other Preoccupations ]] by John Diamond ---- .'''p47 Ch 2 The Vitamin Craze: Linus Pauling's Ironic Legacy''' .13 vitamins .9 soluble:'''[[ https://en.wikipedia.org/wiki/Thiamine | B₁ thiamine ]]''' '''[[ https://en.wikipedia.org/wiki/Riboflavin | B₂ riboflavin ]] [[ https://en.wikipedia.org/wiki/Niacin | B₃ niacin, nicotinic acid ]]''' [[ https://en.wikipedia.org/wiki/Adenine | B₄ adenine ]] '''[[ https://en.wikipedia.org/wiki/Pantothenic_acid | B₅ pantothenic acid ]] [[ https://en.wikipedia.org/wiki/Pyridoxine | B₆ pyrodoxine ]] [[ https://en.wikipedia.org/wiki/Biotin | B₇ biotin ]]''' [[ https://en.wikipedia.org/wiki/Inositol | B₈ inositol ]] '''[[ https://en.wikipedia.org/wiki/Folate | B₉ folic acid ]]''' [[ https://en.wikipedia.org/wiki/4-Aminobenzoic_acid | B₁₀ PABA paramonobenzoic acid ]] B₁₁ salicylic acid '''[[ https://en.wikipedia.org/wiki/Vitamin_B12 | B₁₂ cobalamin ]] [[ https://en.wikipedia.org/wiki/Vitamin_C | C ascorbic acid ]]''' .4 insoluble:'''[[ https://en.wikipedia.org/wiki/Vitamin_A | A retinol ]] [[ https://en.wikipedia.org/wiki/Vitamin_D | D calciferol ]] [[ https://en.wikipedia.org/wiki/Vitamin_E | E tocopherol ]] [[ https://en.wikipedia.org/wiki/Vitamin_K | K phylloquinone ]]''' .p48 [[ https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105975 | 2011 UMinn women taking multivitamins die at higher rates ]] .p48 [[ https://www.nih.gov/news-events/news-releases/nih-funded-study-shows-increased-prostate-cancer-risk-vitamin-e-supplements#:~:text=The%20findings%20showed%20that%2C%20per,those%20who%20took%20a%20placebo. | 2011 Cleveland Clinic men taking vitamin E risk prostate cancer ]] .p48 Seven previous studies show vitamins risk cancer, heart disease, and shortened lives [Citation needed] . are these association or double-blind-trial causal? Perhaps people at higher risk are motivated to take vitamins .p49-50 Linus Pauling accomplishments .p51 1966, 65yo Pauling gets letter from biochemist [[ https://en.wikipedia.org/wiki/Irwin_Stone | Irwin Stone ]] suggesting 3000mg Vitamin C for longevity .p52 [[ https://en.wikipedia.org/wiki/Vitamin_C_and_the_Common_Cold_(book) | Vitamin C and the Common Cold ]] .p53 [[ https://jamanetwork.com/journals/jama/article-abstract/259054 | Vitamins for Prevention of Colds ]] December 19, 1942 DONALD W. COWAN, M.D.; HAROLD S. DIEHL, M.D.; A. B. BAKER, M.D. [[ https://www.mv.helsinki.fi/home/hemila/CC/Cowan_1942_ch.pdf | full paper PDF ]] (19th, not 14th . https://en.wikipedia.org/wiki/Daniel_David_Palmer ... vitamin C no effect on colds .p54 Pauling persisted, attributed cold symptoms to allergies. .p54 1971 Glasgow Ewan Cameron claimed 10g/d Vitamin C helped cancer patients, but those patients started healthier .p55 1971 Pauling claimed 10% cancer decrease, in 1977 claimed 75% cancer decrease, someday maximum age 150yo .p55 1979/Sep Moertel [[ https://www.nejm.org/doi/abs/10.1056/nejm197909273011303 | Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer ]] .p55 1985/Jan Moertel [[ https://www.nejm.org/doi/abs/10.1056/NEJM198501173120301 | High-Dose Vitamin C versus Placebo in the Treatment of Patients with Advanced Cancer Who Have Had No Prior Chemotherapy — A Randomized Double-Blind Comparison ]] .Fanatic: one who can't change his mind and won't change the subject [[ https://babel.hathitrust.org/cgi/pt?id=uva.x000855881&seq=111&q1=fanatic | Esar's Comic Dictionary 1943 ]] .p56 Pauling claims vitamins as cure-all .p57 [[ https://time.com/archive/6719934/the-new-scoop-on-vitamins/ | April 6 1992 Time article by Anastasia Toufexis ]] . Pauling died of prostate cancer August 19, 1994, Pauling and Ava's ashes interred in [[ https://www.findagrave.com/memorial/22440/linus-pauling | Oswego Pioneer Cemetery ]] near parents' graves . [[ https://www.google.com/maps/place/Oswego+Pioneer+Cemetery/@45.4002154,-122.684735,77m/data=!3m1!1e3!4m6!3m5!1s0x5495730007264e61:0xa371e6240e7313ab!8m2!3d45.4009805!4d-122.6836051!16s%2Fg%2F11wbwpxr78?entry=ttu&g_ep=EgoyMDI0MTIxMS4wIKXMDSoASAFQAw%3D%3D | Probably Here ]] Northwest of Stafford Road, entrance on northeast, 5 parking spots on one lane road through cemetery .p58 1994 [[ https://www.nejm.org/doi/full/10.1056/NEJM199404143301501 | Finnish smokers given vitamin E, beta carotine more likely to die of lung cancer or heart disease ]] placebo control .p59 1996 [[ https://academic.oup.com/jnci/article-abstract/96/23/1743/2521077?redirectedFrom=fulltext&login=false | Asbestos Beta Carotine Retinol ]] placebo control .p59 2004 [[ https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17138-9/abstract | Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis ]] .p59 2005 [[ https://www.acpjournals.org/doi/10.7326/0003-4819-142-1-200501040-00110 | Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality ]] free .p61 etc. "antioxidant paradox" ... free radicals ''might'' also hinder immune reaction to bacteria and cancer cells ---- .'''p65 Ch 3 The Supplement Industry Gets a Free Pass: Neutering the FDA''' .p66 [[ https://en.wikipedia.org/wiki/Pure_Food_and_Drug_Act | 1906 Pure Food and Drug Act ]] chemist [[ https://en.wikipedia.org/wiki/Harvey_Washington_Wiley | Harvey Washington Wiley ]] .p67 [[ https://en.wikipedia.org/wiki/Samuel_Hopkins_Adams | Samuel Hopkins Adams ]] [[ https://en.wikipedia.org/wiki/Collier%27s | Colliers ]] [[ https://en.wikisource.org/wiki/The_Great_American_Fraud | The Great American Fraud ]] .p68 [[ https://en.wikipedia.org/wiki/Upton_Sinclair | Upton Sinclair ]] .p69 [[ https://en.wikipedia.org/wiki/Pure_Food_and_Drug_Act | Pure Food and Drug Act ]] of 1906 .p70 [[ https://en.wikipedia.org/wiki/Food_and_Drug_Administration | Food, Drug, and Insecticide Administration ]] .p70 [[ https://en.wikipedia.org/wiki/Elixir_sulfanilamide | Elixir sulfanilamide ]] 72% [[ https://en.wikipedia.org/wiki/Diethylene_glycol | Diethylene glycol ]] .p71 [[ https://en.wikipedia.org/wiki/Federal_Food,_Drug,_and_Cosmetic_Act_of_1938 | Food, Drug, and Cosmetic Act of 1938 ]] required safety testing, but not effectivenss .p71 [[ https://en.wikipedia.org/wiki/Gr%C3%BCnenthal | Chemie Grünenthal ]] [[ https://en.wikipedia.org/wiki/Thalidomide | thalidomide ]] sedative [[ https://en.wikipedia.org/wiki/Thalidomide_scandal | phocomelia and other deformities ]] .p72 [[ https://en.wikipedia.org/wiki/National_Health_Federation | National Health Federation ]] NHF supplement lobbying group founded by [[ https://en.wikipedia.org/wiki/Fred_J._Hart_(businessman) | Fred Hart ]], [[ https://en.wikipedia.org/wiki/Hoxsey_Therapy | Harry Hoxley ]], [[ https://www.organicsbylee.com/learn/about-dr-lee/ | Royal Lee ]], [[ https://cancercontrolsociety.org/ | Kirkpatrick Dilling ]], [[ https://www.herbalgram.org/resources/herbalgram/issues/61/table-of-contents/article2653/ | Bruce Halstead ]], [[ http://www.watersoflifecleansing.com/v.e.irons-vitratox-founder | Victor Earl Irons ]] .p75 [[ https://en.wikipedia.org/wiki/The_Proxmire_Amendment | Rogers-Proxmire Amendment of 1976 ]] .p77 [[ https://multcolib.bibliocommons.com/v2/record/S152C242858 | Natural Causes Death, Lies, and Politics in America's Vitamin and Herbal Supplement Industry ]] Dan Hurley 1957- .p78 1991 [[ https://www.congress.gov/bill/102nd-congress/house-bill/2597 | Food, Drug, Cosmetic, and Device Enforcement Amendments ]] Henry Waxman and David Kessler .p83 [[ https://www.congress.gov/bill/103rd-congress/senate-bill/784?q=%7B%22search%22%3A%22Dietary+Supplement+Health+and+Education+Act%22%7D&s=4&r=1 | Dietary Supplement Health and Education Act of 1994 ]] .p88 [[ https://en.wikipedia.org/wiki/Merck | Merck ]] and [[ https://en.wikipedia.org/wiki/Rofecoxib | Vioxx ]] .p90 [[ https://en.wikipedia.org/wiki/Trick_or_Treatment%3F | Trick or Treatment? ]] Simon Singh 2009 .p91 1983 to 2004, 1.3 million reports of adverse reactions to supplements, 175K hospitalizations, 139 deaths .p92 Harris poll public believes: .68% believe manufacturers report side effects, .58% believe herbals require FDA approval .55% believe scientific evidence is required for product claims ---- .'''p94 Ch 4 Fifty-One Thousand New Supplements: Which Ones Work?''' .p95 [[ https://en.wikipedia.org/wiki/James_Lind | James Lind ]] [[ https://en.wikipedia.org/wiki/Scurvy | Scurvy ]] .p95 [[ https://en.wikipedia.org/wiki/Clinical_trial | Clinical Trials ]] 3 phases .p96 Phase 3 for [[ https://en.wikipedia.org/wiki/Rotavirus_vaccine#RotaTeq | RotaTeq ]] 70 thousand children, eleven countries, four years, $350M .p96 [[ https://en.wikipedia.org/wiki/National_Center_for_Complementary_and_Integrative_Health | NCCAM ]] ''might'' test after marketing, useless/harmful results might get published, but no recall or warnings on product .p97 NCCAM spent $1.6B between 1999 and 2013 (book) on silly studies, now focuses on supplements and pain relief .p98 [[ https://en.wikipedia.org/wiki/Peter_Medawar | Peter Medawar ]] "kindly conspiracy in which everybody has the best intentions" ... "The controlled clinical trial is an attempt to avoid being taken in by this conspiracy of goodwill" .p99 [[ https://en.wikipedia.org/wiki/Steven_Novella | Steven Novella ]] " ... they often make claims that are not backed by evidence." .p99 [[ https://www.thelancet.com/journals/laneur/article/PIIS1474-4422%2812%2970206-5/abstract | Lancet Neurology 2012 ginko biloba ]]?s&_sf_s=Burzynski+OTA .p99 [[ https://jamanetwork.com/journals/jama/fullarticle/194814 | St Johns Wort and Depression JAMA 2002 ]] .p100 [[ https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/411743 | 2007 garlic and cholesterol ]] .p101 [[ https://jamanetwork.com/journals/jama/fullarticle/1104439 | 2011 saw palmetto and prostate ]] .p102 [[ https://jamanetwork.com/journals/jama/fullarticle/1217238 | 2011 milk thistle and hepatitis ]] .p103 [[ https://www.nejm.org/doi/full/10.1056/NEJMoa052771 | 2006 Glucosamine and/or Chondroitin Sulfate for Painful Knee Osteoarthritis ]] .p103 [[ https://jamanetwork.com/journals/jama/fullarticle/197760 | 2003 Echinacea for colds ]] .p103 [[ https://jamanetwork.com/journals/jama/article-abstract/1357266 | 2012 Omega-3 Fatty Acid for Cardiovascular ]] .p105 [[ https://www.nejm.org/doi/full/10.1056/NEJMe1206858 | Vitamin D ]] Effective Dose 600iu 15 minute sunlight 2xWeek .p106 [[ https://womenshealth.gov/a-z-topics/folic-acid | Folic acid ]] ---- .'''p111 Ch 5 Menopause and Aging: Suzanne Somers Weighs In''' .p113 menopause 5 to 8 year process begins with irregular periods by age 45 .p113 Suzanne Somers 7 Dwarves of Menopause: Itchy, Bitchy, Sweaty, Sleepy, Bloated, Forgetful, and All-Dried-Up" .p115 [[ https://jamanetwork.com/journals/jama/fullarticle/195120 | hormone replacement ]] .p122 [[ https://www.jstor.org/stable/26059727 | No truth to the Fountain of Youth ]] ---- .'''p128 Ch 6 Autism's Pied Piper: Jenny !McCarthy's Crusade''' .p129 [[ https://en.wikipedia.org/wiki/Bernard_Rimland | Bernard Rimland ]] .p129 [[ https://en.wikipedia.org/wiki/Autism_Research_Institute | DAN Defeat Autism Now ]] .p130-132 18 "causes" of autism with odd treatments .p133 [[ https://en.wikipedia.org/wiki/Ami_Klin | Ami Clin ]] .p133 [[ https://www.nature.com/articles/nature12715 | Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism ]] ---- .'''p140 Ch 7 Chronic Lyme Disease: The Blumenthal Affair''' .p144 [[ https://en.wikipedia.org/wiki/Lyme_disease | Lyme Disease ]] , [[ https://en.wikipedia.org/wiki/Ixodes_scapularis | Ixodes deer ticks ]] .p144 [[ https://en.wikipedia.org/wiki/Willy_Burgdorfer | bacteriologist Willy Bergdorfer ]] [[ https://en.wikipedia.org/wiki/Borrelia_burgdorferi | Borrelia burgdorferi ]] .p145 First stage bull's-eye rash, days to weeks . If untreated, second stage, spreads to other parts of body, fatigue, swelling, rash, joint pain, 15% meningitis, Bell's palsy, 5% carditis . Third stage months later, 10% experience arthritis . Resolves faster if treated early, fewer symptoms later, antibiotics for 2 to 4 weeks .p146 alternate healers claim fourth stage Chronic Lyme disease with way more symptoms .p147 [[ https://underourskin.com/ | Under Our Skin ]] grab bag of symptoms and supplements .p148 [[ https://en.wikipedia.org/wiki/Wolf-Dieter_Storl | Wolf Storl ]] teasel cure (affiliated with planet Mars) .p149 [[ https://www.cancerresearchuk.org/about-cancer/treatment/complementary-alternative-therapies/individual-therapies/rife-machine-and-cancer | Rife machine ]] .p151 [[ https://www.nejm.org/doi/abs/10.1056/NEJMra072023 | A Critical Appraisal of “Chronic Lyme Disease” ]] Feder et al 2007 NEJM .p153 [[ https://www.idsociety.org/ | Infectious Disease Society of America IDSA ]] .[[ https://academic.oup.com/cid/article/43/9/1089/422463 | "Statement by IDSA against" ]] actually, a long description of therapies, with a paragraph of "Theraputic modalities not recommended" and 19 more "not recommendeds" scattered through this 46 page "Guidelines" paper. "Statement ... against" is misleading. .p154 Connecticut Attorney General [[ https://en.wikipedia.org/wiki/Richard_Blumenthal | Richard Blumenthal ]] sues IDSA for violating antitrust laws. .p157 IDSA forms new and different panel, public hearings, [[ https://academic.oup.com/cid/article-abstract/51/1/1/297544 | New 2010 Report ]], Chronic Lyme isn't real .p159 Science, Politics, and Values: The Politicization of Professional Practice Guidelines .[[ https://jamanetwork.com/journals/jama/article-abstract/183345 | summary ]][[ https://papers.ssrn.com/sol3/Delivery.cfm?abstractid=1364445 | pdf ]] "The scientific process is not democratic — no amount of desire for different results can establish them — and inconsistent findings create true controversy only when their methods are of comparable validity." ---- .'''p163 Ch 8 Curing Cancer: Steve Jobs, Shark Cartilage, Coffee Enemas, and More''' .p163 [[ https://www.nytimes.com/2011/10/21/technology/book-offers-new-details-of-jobs-cancer-fight.html?searchResultPosition=1] | NYT article about Steve Jobs pancreatic cancer woowoo, then full tilt science later ]] .p165 [[ https://cdn.centerforinquiry.org/wp-content/uploads/sites/29/2002/05/22164744/p45.pdf | Dynamizer ]] .Physicist Robert Millikan said, "They are the kind of devices a ten-year-old would build to fool an eight-year-old." .p167 [[ https://en.wikipedia.org/wiki/Hoxsey_Therapy | Harry Hoxsey ]] "The world is made of two kinds of people - 'dem that takes and them that gets took" .p168 [[ https://en.wikipedia.org/wiki/Andrew_Conway_Ivy| Andrew Ivy ]] [[ https://en.wikipedia.org/wiki/Krebiozen | Krebiozen ]] mineral oil and creatine. .p170 [[ https://en.wikipedia.org/wiki/Max_Gerson | Max Gerson ]] "therapies" fooled Steve Jobs .p171 [[ https://en.wikipedia.org/wiki/Sharks_Don%27t_Get_Cancer | Shark Cartilage ]] William Lane (stomach acid destroys cartilage proteins ---- .'''p173 Ch 9 Sick Children, Desperate Parents: Stanislaw Burzynski's Urine Cure''' .p175 [[ https://en.wikipedia.org/wiki/Burzynski_Clinic | Stanislaw Burzynski ]] antineoplaston therapy . urine-derived peptieds, peptide derivatives, and mixtures . "Galileo's Lawyer: Courtroom Battles in Alternative Health, Complementary Medicine and Experimental Treatments" Jaffe, Richard (2008) .p177 [[ https://en.wikipedia.org/wiki/Gary_Null | Gary Null ]] The Suppression of Cancer Cures" in Penthouse October 1979 .p183 [[ https://en.wikipedia.org/wiki/Burzynski_Clinic | Burzynski Clinic ]] .p184 [[ https://jamanetwork.com/journals/jama/article-abstract/397590 | 1992 'Antineoplastons' An Unproved Cancer Therapy - Saul Green, PhD ]] .p187 [[ https://www.dukehealth.org/find-doctors-physicians/henry-s-friedman-md | Henry S. Friedman @Duke ]] "no one has shown ... that the therapy works ... incredible ... you can do a cancer study on as few as 30 or 40 patients. .p187 [[ https://pmc.ncbi.nlm.nih.gov/articles/PMC3623294/ | PLX4032 ]] tested on 32 patients, shrunk all tumors . [[ https://en.wikipedia.org/wiki/Vemurafenib | Vemurafenib ]] approved by FDA 2011 August 17 . p191 1 year after diagnosis, 2012 June 1 Billie Bainbridge dies . p192 Burzynski sells [[ https://www.aminocare.com | supplements and creams. ]] Suzanne Somers promotes them. . p193 [[ https://search.worldcat.org/title/464593321 | The Emperor of All Maladies: A biography of Cancer ]] by [[ https://en.wikipedia.org/wiki/Siddhartha_Mukherjee | Siddhartha Mukherjee ]] ---- .'''p197 Ch 10 Magic Potions in the Twenty-First Century: Rashid Buttar and the Lure of Personality''' .p198 [[ https://www.imdb.com/title/tt0734609/ | Twilight Zone: One for the Angels ]] [[ https://en.wiktionary.org/wiki/kwakzalver | kwakzalver ]] salesman bargains for a little girl's life .p203 [[ https://en.wikipedia.org/wiki/Rashid_Buttar | Rashid Buttar ]][[ https://en.wikipedia.org/wiki/Chelation_therapy | chelation ]] skin ointment for autism .p205 [[ https://rationalwiki.org/wiki/Desiree_Jennings | Desiree Jennings ]] .p209 chelation mercury amounts the same for autistic and normal children .p209 mercury damage permanent, even after chelation (to prevent further damage) .p210 hucksters: "tests not needed, it works because I know it works" .p211 Buttar chelating cream $150 per small vial .p212 New Yorker's Michael Specter: "We hate Big Pharma, but we leap into the arms of Big Placebo" .p214 Chelation also binds to calcium, [[ https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5508a3.htm | fatalities ]] . August 2003 Oregon 53yo woman chelated by naturopathic physician with 700mg IV EDTA from [[ https://npino.com/pharmacy/1922284751-creative-compounds/ | Creative Compounding Wilsonville OR ]] .p216 Buttar "swine flu lost its virulence" in Mexico ... 47M infected, 250,000 hospitalized, 12,000 dead including 1,100 children .p218 brought before North Carolina board, not punished ---- .'''p223 Ch 11 The Remarkably Powerful, Highly Underrated Placebo Response''' .p226 "Vitamin O": salt water . [[ https://www.webmd.com/vitamins/ai/ingredientmono-452/vitamin-o | FTC fined manufacturer $375K ]] .p227 The doctor who fails to have a placebo effect on his patients should be a pathologist" attributed to J. N. Blau .p230 [[ https://en.wikipedia.org/wiki/Endorphins | Rabi Simantov and Solomon Snyder ]] discovered morphine brain receptor . Endorphins ( '''endo'''genous '''morphin'''e ) brain peptides stimulate "morphine receptor" . [[ https://en.wikipedia.org/wiki/Naloxone | naloxone ]] blocks those receptors .p231 Ancient Chinese did not believe in dissection, knew nothing about nervous system anatomy, inserted needles randomly .p233 >86 people died from acupuncture .p238 [[ https://en.wikipedia.org/wiki/Oscillococcinum | oscillococcinum ]] homogenized heart and liver of duck diluted 1e-400 .p239 cough and cold medicines containing pseudoephedrine are dangerous for small children, do little to relieve symptoms. ---- .'''p241 Ch 12 When Alternate Medicine Becomes Quackery''' .p242 [[ https://en.wikipedia.org/wiki/God%27s_Perfect_Child | God's Perfect Child ]] Caroline Fraser 1999 Christian Science [[ https://wccls.bibliocommons.com/v2/record/S143C4310788 | Tigard Lib ]] .p243 [[ https://en.wikipedia.org/wiki/Joseph_Mercola | Joseph Mercola ]] antivax, AIDS isn't HIV, treat cancer with enemas .p244 [[ https://en.wikipedia.org/wiki/Andrew_Weil | Andrew Weil ]] and liver-toxic [[ https://en.wikipedia.org/wiki/Kava | kava ]] (if extracted with solvents) .p246 [[ https://en.wikipedia.org/wiki/God_Is_My_Broker | God is my Broker ]] [[ https://archive.nytimes.com/www.nytimes.com/books/business/9805buckley-interview.html | interview ]] .p248 Mercola products gross $7M/year ---- .'''p253 Epilogue: Albert Schweitzer and the Witch Doctor: A Parable''' .p253 [[ https://catalog.wccls.org/polaris/search/title.aspx?ctx=1.1033.0.0.6&pos=1&cn=3182157 | Norman Cousins "Anatomy of an Illness" ]] .p254 Witch doctor triage .minor illness: herbs in a bag with instructions .psychological problems: incantations .major problems: sent to Dr. Schweitzer .p258 Douglas Adams . "Isn't it enough to see that a garden is beautiful, without having to believe that there are fairies at the bottom of it?"