=== Modern Virology, Dimmock, 2007 === ---- p139 s9.5 Herpesviruses HSV1: 70 genes, 153kbp . α immediate early phase       β early       γ late p141: UL41   VHS = virion host shutoff. A ribonuclease that degrades cytoplasmic mRNA that is being translated. Decreases the half-life of all mRNA in the cell, favoring protein expression from viral genes that are being actively transcribed. Later, a more specific host shutoff function ('''''what'' function???''') is expressed, and UL41 is inactivated by binding to VP16. ------- === Basic Virology, Wagner, 2008 3rd Ed ISBN 978-1-4051-4715-6 === ---- used, around $40