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.p006 .p039 .p046 .p059 .p072 .p074 .p081 .p095 .p096 .p100 .p102 .p103 .p105 .p108 .p113 .p114 .p115 .p116 .p116 .p117 .p117 .p139 .p146 .p149 .p157 .p160 .p165 .p169 .p196 .p196 .p203 .p222 .p223 .p225 .p229 .p246 . |
. copyright 2022, written earlier by large team .p006 [[ https://en.wikipedia.org/wiki/William_Foege | Bill Foege ]] CDC `977-`993 .p039 [[ https://en.wikipedia.org/wiki/MRNA_vaccine | Messenger RNA Vaccine, ]] 6 billion doses in 2021 .p046 need well funded global organization focused on pandemic prevention .p059 [[ https://champshealth.org/ | CHAMPS ]] Child Health And Mortality Protection Surveillance global network .p072 [[ https://scholar.google.com/citations?user=TPWwr18AAAAJ&hl=en | Michael Famulare ]] estimated 570 (80 to 1500 90% confidence) infected when first two patients identified .p074 2020 March 30 NYT [[ https://www.nytimes.com/2020/03/01/health/coronavirus-washington-spread.html | Coronavirus May Have Spread in U.S. for Weeks, Gene Sequencing Suggest ]] .p096 flu cases dropped 99% in 2020-21 compared to 2019-2020 .p100 contact tracing requires widespread testing, fast results, and contacting people quickly .p102 droplets larger than 5μm, aerosols smaller. Heavier droplets carry more virus, but fall to ground within feet .p103 COVID viruses electrically charged, attract lung substances that slow aerosol drying .p104 Social distancing works, nothing magical about six feet .p105 Masks 1910 [[ https://en.wikipedia.org/wiki/Wu_Lien-teh | Wu Lien-teh ]] Maylayan physician fighting [[ https://en.wikipedia.org/wiki/Pneumonic_plague | pneumonic plague ]] in Manchuria .p108 N mask straps around back of head, KN mask straps around ears (unless ears flap forward like mine) .p113 [[ https://en.wikipedia.org/wiki/Hydroxychloroquine | hydroxychloroquine ]] blocked COVID in monkeys, buy humans have different pathway .p114 [[ https://en.wikipedia.org/wiki/Cytokine_storm | cytokine storm ]], blood vessels leak fluid into organs and lungs, the overreaction causes low blood pressure, organ failure, and death .p115 [[ https://en.wikipedia.org/wiki/Convalescent_plasma | convalescent plasma ]] and [[ https://en.wikipedia.org/wiki/Remdesivir | remdesivir ]] not verty effectove .p116 [[ https://en.wikipedia.org/wiki/Monoclonal_antibody | monoclonal antibodies mAbs ]] .p116 [[ https://en.wikipedia.org/wiki/Sotrovimab | Sotrovimab ]] isolated from [[ https://en.wikipedia.org/wiki/SARS | SARS ]] and modified (not effective ahttps://www.nih.gov/gainst Omicron) .p117 [[ https://en.wikipedia.org/wiki/Merck_%26_Co. | Merck ]] [[https://en.wikipedia.org/wiki/Molnupiravir | molnupiravir ]] .p117 [[ https://en.wikipedia.org/wiki/Nirmatrelvir/ritonavir | Paxlovid ]] [[ https://en.wikipedia.org/wiki/Pfizer | Pfizer ]] .p139 vaccines, from disease identification to Vaccines to 50% global vaccination || Disease || Identified || Vaccine Available || 50% || || Whooping Cough || 1906 || 1948 || 1986 || || Polio || 1908 || 1955 || 1985 || || Measles || 1953(?) || 1963 || 1987 || || COVID || 2020 || 2021 || 2021 || .p146 [[ https://cleanroomtechnology.com/vaccine-manufacturing-facilities-and-cleanrooms-explained-176581 | vaccine factory ]] standards, temperature, airflow, wall corner curvature .p149 [[ https://en.wikipedia.org/wiki/COVAX | COVAX ]] .p157 We were good, but we were also lucky (SARS and MERS experience helped) .p160 [[ https://www.hptn.org/news-and-events/announcements/remembering-dr-stephaun-e-wallace | Stephaun Wallace ]] at [[ https://www.fredhutch.org/en.html | Fred Hutch ]] [[ https://www.seattletimes.com/life/seattle-medical-and-ballroom-community-mourns-loss-of-stephaun-e-wallace/ | died 2023 age 45 ]] .p165 "cookbook by [[ https://en.wikipedia.org/wiki/David_Chang | David Chang ]] analogy .p169 [[ https://www.who.int/ | WHO ]] [[ https://www.who.int/news-room/feature-stories/detail/vaccine-efficacy-effectiveness-and-protection | vaccine approval ]] .p196 Pentagon budget $700B/year, [[ https://www.nih.gov/ | NIH ]] $43B/year .p196 Bill Foege CDC successor [[ https://en.wikipedia.org/wiki/James_O._Mason | James Mason ]] 1983-89) closed down CDC bioterrorism program .p203 5 million child deaths per year, main focus of Gates Foundation .p222 [[ https://en.wikipedia.org/wiki/Transdermal_patch | Microneedle patches ]] .p223 Gates (and I) believe COVID was animal spillover, not lab leak .p225 Inattention: public health needs modernization, one state health department ran 20 year old software .p229 [[ https://en.wikipedia.org/wiki/Crimson_Contagion | Crimson Contagion ]] outbreak simulation .p246 [[ https://en.wikipedia.org/wiki/Telehealth | telehealth saves time ]] |
Bill Gates Books
How To Prevent the Next Pandemic
- copyright 2022, written earlier by large team
p006 Bill Foege CDC 977-993
p039 Messenger RNA Vaccine, 6 billion doses in 2021
- p046 need well funded global organization focused on pandemic prevention
p059 CHAMPS Child Health And Mortality Protection Surveillance global network
p072 Michael Famulare estimated 570 (80 to 1500 90% confidence) infected when first two patients identified
p074 2020 March 30 NYT Coronavirus May Have Spread in U.S. for Weeks, Gene Sequencing Suggest
- p096 flu cases dropped 99% in 2020-21 compared to 2019-2020
- p100 contact tracing requires widespread testing, fast results, and contacting people quickly
- p102 droplets larger than 5μm, aerosols smaller. Heavier droplets carry more virus, but fall to ground within feet
- p103 COVID viruses electrically charged, attract lung substances that slow aerosol drying
- p104 Social distancing works, nothing magical about six feet
p105 Masks 1910 Wu Lien-teh Maylayan physician fighting pneumonic plague in Manchuria
- p108 N mask straps around back of head, KN mask straps around ears (unless ears flap forward like mine)
p113 hydroxychloroquine blocked COVID in monkeys, buy humans have different pathway
p114 cytokine storm, blood vessels leak fluid into organs and lungs, the overreaction causes low blood pressure, organ failure, and death
p115 convalescent plasma and remdesivir not verty effectove
p116 Sotrovimab isolated from SARS and modified (not effective ahttps://www.nih.gov/gainst Omicron)
p117 Merck molnupiravir
- p139 vaccines, from disease identification to Vaccines to 50% global vaccination
Disease |
Identified |
Vaccine Available |
50% |
Whooping Cough |
1906 |
1948 |
1986 |
Polio |
1908 |
1955 |
1985 |
Measles |
1953(?) |
1963 |
1987 |
COVID |
2020 |
2021 |
2021 |
p146 vaccine factory standards, temperature, airflow, wall corner curvature
p149 COVAX
- p157 We were good, but we were also lucky (SARS and MERS experience helped)
p165 "cookbook by David Chang analogy
p169 WHO vaccine approval
p196 Pentagon budget $700B/year, NIH $43B/year
p196 Bill Foege CDC successor James Mason 1983-89) closed down CDC bioterrorism program
- p203 5 million child deaths per year, main focus of Gates Foundation
p222 Microneedle patches
- p223 Gates (and I) believe COVID was animal spillover, not lab leak
- p225 Inattention: public health needs modernization, one state health department ran 20 year old software
p229 Crimson Contagion outbreak simulation