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| || '''Farnesyl-PP''' || Farnesyl Diphosphate Synthase || '''Geranyl-PP''' || makes Ubiquinone || || Squalene || Squalene Synthase || '''Farnesyl-PP''' || || Squalene epoxide || Squalene Epoxidase || Squalene || '''why not block this step instead???''' || |
|| '''Farnesyl-PP''' || Farnesyl Diphosphate Synthase || '''Geranyl-PP''' || makes Ubiquinone/CoQ,,10,, || || Squalene || Squalene Synthase || '''Farnesyl-PP''' || '''why not block this step instead???''' || || Squalene epoxide || Squalene Epoxidase || Squalene || '''or block this step?''' || |
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| ||<-3:>postulated alternative pathway 1 || | ||<-3:>''postulated alternative pathway 1'' || |
| Line 24: | Line 24: |
| ||<-3:>postulated alternative pathway 2 || | ||<-3:>''postulated alternative pathway 2'' || |
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| ||<-3:>Also made from Mevalonate, suppressed by statins || ||'''[[http://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate|Isopentenyl-PP]]'''||<-2>{{http://upload.wikimedia.org/wikipedia/commons/thumb/8/8a/Isopentenyl_pyrophosphate.svg/200px-Isopentenyl_pyrophosphate.svg.png | | width=200}}|| ||Isopentenyl ? || ||adenosine ? || ||tRNAs ? || || ? || ||'''[[http://en.wikipedia.org/wiki/Geranyl_pyrophosphate|Geranyl-PP]]'''||<-2>{{http://upload.wikimedia.org/wikipedia/commons/thumb/f/f0/Geranyl_pyrophosphate.png/320px-Geranyl_pyrophosphate.png | | width=200}}|| ||[[http://en.wikipedia.org/wiki/Prenylation|Prenylated proteins]]|| ||[[http://en.wikipedia.org/wiki/Heme_A|Heme A]] || || || ||'''[[http://en.wikipedia.org/wiki/Farnesyl_pyrophosphate|Farnesyl-PP]]'''||<-2>{{http://upload.wikimedia.org/wikipedia/commons/thumb/5/53/Farnesyl_pyrophosphate.png/320px-Farnesyl_pyrophosphate.png | | width=200}}|| ||[[http://en.wikipedia.org/wiki/Ubiquinone|Coenzyme Q10]]|| ||[[http://en.wikipedia.org/wiki/Dolichol|Dolichol]] || || || || || || || |
||<-3:><<BR>><<BR>>'''Also made from Mevalonate, suppressed by statins''' || ||'''[[http://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate|Isopentenyl-PP]]'''||{{http://upload.wikimedia.org/wikipedia/commons/thumb/8/8a/Isopentenyl_pyrophosphate.svg/200px-Isopentenyl_pyrophosphate.svg.png | | width=200}}|| || ||Isopentenyl ? || || || ||adenosine ? || || || ||tRNAs ? || || || || ? || || || ||'''[[http://en.wikipedia.org/wiki/Geranyl_pyrophosphate|Geranyl-PP]]'''||{{http://upload.wikimedia.org/wikipedia/commons/thumb/f/f0/Geranyl_pyrophosphate.png/320px-Geranyl_pyrophosphate.png | | width=200}}|| || ||[[http://en.wikipedia.org/wiki/Prenylation|Prenylated proteins]]|| || ||[[http://en.wikipedia.org/wiki/Heme_A|Heme A]] || || || || || || || ||'''[[http://en.wikipedia.org/wiki/Farnesyl_pyrophosphate|Farnesyl-PP]]'''||{{http://upload.wikimedia.org/wikipedia/commons/thumb/5/53/Farnesyl_pyrophosphate.png/320px-Farnesyl_pyrophosphate.png | | width=200}}|| || ||[[http://en.wikipedia.org/wiki/Ubiquinone|Coenzyme Q,,10,,]]|| || || ||[[http://en.wikipedia.org/wiki/Dolichol|Dolichol]] || || || || || || || || || || || || || || || |
HMGCoA
3-hydroxy-3-methylglutaryl-coenzyme A - pathways
molecule |
made by |
from molecule |
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Acetyl-CoA |
Acetoacetyl-CoA Thiolase |
Acetoacetyl-CoA |
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HMG-CoA |
HMG-CoA Synthase |
Acetyl-CoA |
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Mevalonate |
HMG-CoA Reductase |
HMG-CoA |
statins block this step |
Mevalonate-5-P |
Mevalonate Kinase |
Mevalonate |
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Mevalonate-5-PP |
Phosphomeavalonate Kinase |
Mevalonate-5-P |
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Isopentenyl-PP |
Mevalonate-5-PP Decarboxylase |
Mevalonate-5-PP |
makes Isopentyl adenosome tRNAs |
Dimethylallyl-PP |
Isopentenyl-PP Isomerase |
Isopentenyl-PP |
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Geranyl-PP |
Farnesyl Diphosphate Synthase |
Dimethylallyl-PP |
makes Prenylated proteins, Heme A, Dolichol |
Farnesyl-PP |
Farnesyl Diphosphate Synthase |
Geranyl-PP |
makes Ubiquinone/CoQ10 |
Squalene |
Squalene Synthase |
Farnesyl-PP |
why not block this step instead??? |
Squalene epoxide |
Squalene Epoxidase |
Squalene |
or block this step? |
Lanosterol |
Oxidosqualene Cyclase |
Squalene epoxide |
or block this step? |
Zymosterol |
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Lanosterol |
or block this step? |
postulated alternative pathway 1 |
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Cholest-8(9)-en-3β-ol |
Δ24-reductase |
Zymosterol |
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Lathosterol |
Δ8Δ7-isomerase |
Cholest-8(9)-en-3β-ol |
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7-Dehydrocholesterol |
Lanosterol Oxidase |
Lathosterol |
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Cholesterol |
Δ7-DHC Reductase |
7-Dehydrocholesterol |
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postulated alternative pathway 2 |
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Cholesta-7,24-dien-3β-ol |
Δ8Δ7-isomerase |
Zymosterol |
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7-Dehydrodesmosterol |
Δ5-desaturase |
Cholesta-7,24-dien-3β-ol |
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Desmosterol |
Δ7-reductase |
7-Dehydrodesmosterol |
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Cholesterol |
Desmosterol Δ24-reductase |
Desmosterol |
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Isopentenyl ? |
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adenosine ? |
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tRNAs ? |
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