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Adapted from figures on page 402 and 405 of Biochemistry of Lipids, Lipoproteins, and Membranes 5th Edition 2008 eds: Vance and Vance |
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| || Mevalonate || HMG-CoA Reductase || HMG-CoA || statins block this step || | || Mevalonate || HMG-CoA Reductase || HMG-CoA || [[http://en.wikipedia.org/wiki/Statin|statins]] block this step || |
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| ||[[http://en.wikipedia.org/wiki/Prenylation|Prenylated proteins]]|| || | ||[[http://en.wikipedia.org/wiki/Prenylation|Prenylated proteins]]|| || || |
HMGCoA
3-hydroxy-3-methylglutaryl-coenzyme A - pathways
Adapted from figures on page 402 and 405 of Biochemistry of Lipids, Lipoproteins, and Membranes 5th Edition 2008 eds: Vance and Vance
molecule |
made by |
from molecule |
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Acetyl-CoA |
Acetoacetyl-CoA Thiolase |
Acetoacetyl-CoA |
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HMG-CoA |
HMG-CoA Synthase |
Acetyl-CoA |
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Mevalonate |
HMG-CoA Reductase |
HMG-CoA |
statins block this step |
Mevalonate-5-P |
Mevalonate Kinase |
Mevalonate |
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Mevalonate-5-PP |
Phosphomeavalonate Kinase |
Mevalonate-5-P |
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Isopentenyl-PP |
Mevalonate-5-PP Decarboxylase |
Mevalonate-5-PP |
makes Isopentyl adenosome tRNAs |
Dimethylallyl-PP |
Isopentenyl-PP Isomerase |
Isopentenyl-PP |
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Geranyl-PP |
Farnesyl Diphosphate Synthase |
Dimethylallyl-PP |
makes Prenylated proteins, Heme A, Dolichol |
Farnesyl-PP |
Farnesyl Diphosphate Synthase |
Geranyl-PP |
makes Ubiquinone/CoQ10 |
Squalene |
Squalene Synthase |
Farnesyl-PP |
why not block this step instead??? |
Squalene epoxide |
Squalene Epoxidase |
Squalene |
or block this step? |
Lanosterol |
Oxidosqualene Cyclase |
Squalene epoxide |
or block this step? |
Zymosterol |
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Lanosterol |
or block this step? |
postulated alternative pathway 1 |
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Cholest-8(9)-en-3β-ol |
Δ24-reductase |
Zymosterol |
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Lathosterol |
Δ8Δ7-isomerase |
Cholest-8(9)-en-3β-ol |
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7-Dehydrocholesterol |
Lanosterol Oxidase |
Lathosterol |
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Cholesterol |
Δ7-DHC Reductase |
7-Dehydrocholesterol |
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postulated alternative pathway 2 |
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Cholesta-7,24-dien-3β-ol |
Δ8Δ7-isomerase |
Zymosterol |
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7-Dehydrodesmosterol |
Δ5-desaturase |
Cholesta-7,24-dien-3β-ol |
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Desmosterol |
Δ7-reductase |
7-Dehydrodesmosterol |
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Cholesterol |
Desmosterol Δ24-reductase |
Desmosterol |
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Isopentenyl ? |
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adenosine ? |
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tRNAs ? |
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