HMGCoA
3-hydroxy-3-methylglutaryl-coenzyme A - pathways
molecule |
made by |
from molecule |
|
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Acetyl-CoA |
Acetoacetyl-CoA Thiolase |
Acetoacetyl-CoA |
|
HMG-CoA |
HMG-CoA Synthase |
Acetyl-CoA |
|
Mevalonate |
HMG-CoA Reductase |
HMG-CoA |
statins block this step |
Mevalonate-5-P |
Mevalonate Kinase |
Mevalonate |
|
Mevalonate-5-PP |
Phosphomeavalonate Kinase |
Mevalonate-5-P |
|
Isopentenyl-PP |
Mevalonate-5-PP Decarboxylase |
Mevalonate-5-PP |
makes Isopentyl adenosome tRNAs |
Dimethylallyl-PP |
Isopentenyl-PP Isomerase |
Isopentenyl-PP |
|
Geranyl-PP |
Farnesyl Diphosphate Synthase |
Dimethylallyl-PP |
makes Prenylated proteins, Heme A, Dolichol |
Farnesyl-PP |
Farnesyl Diphosphate Synthase |
Geranyl-PP |
makes Ubiquinone |
Squalene |
Squalene Synthase |
Farnesyl-PP |
|
Squalene epoxide |
Squalene Epoxidase |
Squalene |
why not block this step instead??? |
Lanosterol |
Oxidosqualene Cyclase |
Squalene epoxide |
or block this step? |
Zymosterol |
|
Lanosterol |
or block this step? |
postulated alternative pathway 1 |
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Cholest-8(9)-en-3β-ol |
Δ24-reductase |
Zymosterol |
|
Lathosterol |
Δ8Δ7-isomerase |
Cholest-8(9)-en-3β-ol |
|
7-Dehydrocholesterol |
Lanosterol Oxidase |
Lathosterol |
|
Cholesterol |
Δ7-DHC Reductase |
7-Dehydrocholesterol |
|
postulated alternative pathway 2 |
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Cholesta-7,24-dien-3β-ol |
Δ8Δ7-isomerase |
Zymosterol |
|
7-Dehydrodesmosterol |
Δ5-desaturase |
Cholesta-7,24-dien-3β-ol |
|
Desmosterol |
Δ7-reductase |
7-Dehydrodesmosterol |
|
Cholesterol |
Desmosterol Δ24-reductase |
Desmosterol |
|
Also made from Mevalonate, suppressed by statins |
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Isopentenyl-PP |
|
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Isopentenyl ? |
Isopentenyl-PP |
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adenosine ? |
Isopentenyl-PP |
||
tRNAs ? |
Isopentenyl-PP |
||
? |
Isopentenyl-PP |
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Geranyl-PP |
|
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Prenylated proteins |
Geranyl-PP |
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Heme A |
Geranyl-PP |
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|
Geranyl-PP |
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Farnesyl-PP |
|
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Farnesyl-PP |
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Farnesyl-PP |
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Farnenyl-PP |
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|
Farnenyl-PP |
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Farnenyl-PP |
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