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 .p001

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 .'''Section I: UNLEARNING CYNICISM'''

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 .'''p015 Chapter 1 - Signs and Symptoms'''
 .p015

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 .'''p015 Chapter 1 - God's Own Medicine'''
 .p016 [[ https://en.wikipedia.org/wiki/Noscapine | alpha-narcotine ]] [[ https://en.wikipedia.org/wiki/Papaverine| papaverine ]] [[ https://en.wikipedia.org/wiki/Thebaine | thebaine ]]
 .p022 [[ https://en.wikipedia.org/wiki/Alexander_Wood_(physician) | Alexander Wood ]] invented [[ https://en.wikipedia.org/wiki/Hypodermic_needle | first hypodermic needle 1853 ]] to administer morphine (rather than orally), believed that injection would "cure the appetite" for morphine addiction.
  ."Pandora" repeats myth that morphine overdose injection killed his wife, who actually outlived him by 10 years.
 .p024 [[ https://en.wikipedia.org/wiki/Heinrich_Dreser | Heinrich Dreser ]] responsible for [[ https://en.wikipedia.org/wiki/Aspirin | aspirin ]] and [[ https://en.wikipedia.org/wiki/Heroin | heroin ]] and [[ https://en.wikipedia.org/wiki/Codeine | codeine ]] at [[ https://en.wikipedia.org/wiki/Bayer | Bayer AG ]]

 .p025 [[ https://en.wikipedia.org/wiki/Eli_Lilly_and_Company| Eli Lilly ]] "safe" heroin distributed over-the-counter without prescription in the US in 1900, JAMA "standard of care" in 1906
 .p025 1906 JAMA: heroin standard of care for many respiratory ailments; by 1910 doctors aware of addiction, use declined
 .p027 next, [[ https://en.wikipedia.org/wiki/Thebaine | thebaine ]] a different opium compound. [[ https://en.wikipedia.org/wiki/Oxycodone | oxycodone ]] the synthetic form in 1916,
 .p028 [[ https://en.wikipedia.org/wiki/Purdue_Pharma | Purdue ]] [[ https://en.wikipedia.org/wiki/Oxycodone | OxyContin ]] time release tablet releases immediate addictive dose if chewed

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 .'''p041 Chapter 2 - The Great Margarine Mistake'''
 .p043 [[ https://en.wikipedia.org/wiki/Ancel_Keys | Ancel Keys ]] urged fat restriction
 .po44 [[ https://en.wikipedia.org/wiki/United_States_Senate_Select_Committee_on_Nutrition_and_Human_Needs | 1977 McGovern report ]] food guidelines authored by [[ https://www.commondreams.org/author/nick-motter | Nick Mottern ]] non-scientist reporter
 .p048 conflated unhealthy [[ https://en.wikipedia.org/wiki/Saturated_fat | saturated fats ]] with healthy, essential [[ https://en.wikipedia.org/wiki/Unsaturated_fat | unsaturated fats ]] (some double bonds between carbons)
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 .'''p061 Chapter 3 - Blood From Air'''
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 .'''p097 Chapter 4 America's Master Race'''
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 .'''p131 Chapter 5 - Turning the Mind Inside Out'''
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 .'''p161 Chapter 6 - The Mosquito Liberation Front'''
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 .'''p191 Chapter 7 - Nobel Prize Disease'''
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 .'''p213 Chapter 8 - Learning From the Past'''
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 .p241 Epilogue
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 .'''p015 Chapter 1 - Signs and Symptoms'''
 .p015

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 .'''p015 Chapter 1 - Signs and Symptoms'''
 .p015

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 .'''p015 Chapter 1 - Signs and Symptoms'''
 .p015

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 .'''p015 Chapter 1 - Signs and Symptoms'''
 .p015

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  .'''Section II:. REDISCOVERING ONE ANOTHER'''
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 .'''p097 Chapter 6 - The (Social) Water is Just Fine'''
 .p097
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 .p243 Acknowledgements
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 .'''p114 Chapter 7 - Building Cultures of Trust'''
 .p114

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 .'''p015 Chapter 8 - The Fault is in Our Fault Lines'''
 .p015

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  .'''Section III:. THE FUTURE OF HOPE'''
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 .'''p151 Chapter 9 - Building the World We Want'''
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 .'''p168 Chapter 10 - The Optimism of Activism'''
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 .'''p185 Chapter 11 - Our Common Fate'''
 .p015

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 .p200 Epilogue

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 .p205 Acknowledgements

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 .p209 Appendix A: A Practical Guide to Hopeful Skepticism

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 .p213 Appendix B: Evaluating the Evidence

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 .p217 Chapter Claim Ratings

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 .p225 Notes

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 .p263 Index

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 .p245 Selected Bibliography
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 .p273 About the Author

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 .p275 Index

Pandora's Lab

Seven Stories of Science Gone Wrong

  • Paul A. Offit, M.D. . 2017 . 500 OFFIT 2017 . Hillsboro Library


  • p001 Introduction


  • p015 Chapter 1 - God's Own Medicine

  • p016 alpha-narcotine papaverine thebaine

  • p022 Alexander Wood invented first hypodermic needle 1853 to administer morphine (rather than orally), believed that injection would "cure the appetite" for morphine addiction.

    • "Pandora" repeats myth that morphine overdose injection killed his wife, who actually outlived him by 10 years.
  • p024 Heinrich Dreser responsible for aspirin and heroin and codeine at Bayer AG

  • p025 Eli Lilly "safe" heroin distributed over-the-counter without prescription in the US in 1900, JAMA "standard of care" in 1906

  • p025 1906 JAMA: heroin standard of care for many respiratory ailments; by 1910 doctors aware of addiction, use declined
  • p027 next, thebaine a different opium compound. oxycodone the synthetic form in 1916,

  • p028 Purdue OxyContin time release tablet releases immediate addictive dose if chewed



  • p061 Chapter 3 - Blood From Air

  • p062

  • p066

  • p067

  • p068

  • p070

  • p071

  • p072

  • p072

  • p073

  • p074

  • p074

  • p075

  • p075

  • p076

  • p077

  • p078

  • p078

  • p079

  • p081

  • p081

  • p082

  • p083

  • p084

  • p085

  • p086

  • p086

  • p087

  • p088

  • p090

  • p091

  • p092

  • p094


  • p097 Chapter 4 America's Master Race

  • p097

  • p098

  • p098

  • p100

  • p101

  • p103

  • p104

  • p105

  • p107

  • p107

  • p108

  • p109

  • p111

  • p112

  • p116

  • p118

  • p121

  • p121

  • p121

  • p122

  • p122

  • p122

  • p123

  • p124

  • p125

  • p125

  • p127

  • p128

  • p129


  • p131 Chapter 5 - Turning the Mind Inside Out

  • p132

  • p134

  • p135

  • p136

  • p138

  • p146

  • p147

  • p147

  • p148

  • p148

  • p148

  • p148

  • p149

  • p150

  • p151

  • p152

  • p152

  • p153

  • p153

  • p153

  • p154

  • p154

  • p155

  • p155

  • p156

  • p156

  • p157

  • p157

  • p157

  • p159

  • p159


  • p161 Chapter 6 - The Mosquito Liberation Front

  • p161

  • p162

  • p163

  • p164

  • p165

  • p166

  • p167

  • p167

  • p169

  • p172

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  • p174

  • p175

  • p175

  • p175

  • p182

  • p183

  • p183

  • p184

  • p184

  • p186


  • p191 Chapter 7 - Nobel Prize Disease

  • p192

  • p192

  • p192

  • p195

  • p195

  • p196

  • p198

  • p199

  • p201

  • p202

  • p206


  • p213 Chapter 8 - Learning From the Past

  • p214

  • p214

  • p215

  • p216

  • p217

  • p219

  • p221

  • p222

  • p223

  • p224

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  • p237

  • p237

  • p238

  • p239

  • p239

  • p239

  • p240


  • p241 Epilogue
  • p241


  • p243 Acknowledgements


  • p245 Selected Bibliography
  • p245

  • p246

  • p247

  • p249

  • p253

  • p254

  • p258

  • p259

  • p260

  • p261

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  • p264

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  • p269


  • p273 About the Author


  • p275 Index

PandorasLab (last edited 2026-05-15 06:01:03 by KeithLofstrom)