Diff for "PaulOffit"

Paul Offit Books

Do you Believe in Magic?

The Sense and Nonsense of Alternative Medicine

Paul A. Offit, M.D. - Multco Hollywood 615.5 o328d 2013

• p1 42%/6000 hospitals offer some form of alternative therapies

• p2 Pfizer acquired Alacer megavitamins (Emergen-C)

• p3 M.D. wife Bonnie Fass-Offit

• p3 benign Cutaneous Blue Ne .vus syndrome mimics malignant melanoma, fools most dermatologists

• p4 loss of cartilage beneath kneecap, surgery and 1 year recovery
• p4 enlarged prostate, most men with prostate cat word5m | grep cancer die of something else first, while surgery is brutal

• p5 Chiropractic manipulations can lead to injuries, acupuncture to infection, some megavitamins increase cancer risk

• p7 Introduction: Saving Joey Hofbauer

• p7 laetrile

• p7 1977 Oct 5 neck lump in 7yo Joey Hofbauer, one swollen lymph gland
• p8 Cancer of lymph glands, radiation and chemotherapy 95% chance of recovery

• p11 laetrile "treatment" by psychologist Michael B. Schachter

• p13 after six months of unconventional treatments, Joey had 17 swollen lymph glands, liver damage (megadose vitamin A), possible cyanide poisoning

• p14 Laetrile Robert BradfordJohn Birch Society

• p15 William D. Kelley Clinic Mexico Steve McQueen (smoker, asbestos exposure in the marines) pleural mesothelioma died age 50

• p16 N Engl J Med 1977;296:1167-1168 May 19 (not 26) 1977, Laetrilomania

• p17 Judge rules alternatives adequate . p18 Joey dies 1980 July 10, McQueen dies 1980 Nov 7

• p18 Charles Moertel teams at Mayo, UCLA, Sloan-Kettering study 178 cancer patents on laetrile and high dose vitamins

  • no stabilization or improvement, median survival 4.8 moths, "... not justified", FDA bans laetrile in 1987

• p21 Fringe group National Health Federation criticised by American Cancer Society and Quackwatch

• p25 Ch 1 Recovering the Past: Mehmet Oz and His Superstars

• p25 Mehmet Oz Dr. Oz Show

• p28 Hippocrates 400 BC humors acupuncture chi

• p29 Benjamin Rush bloodletting hastened death of George Washington (with Epiglottitis) and Benjamin Franklin

• p30 Edward Jenner 1796 smallpox vaccine

• p30-31 John Snow cholera Robert Koch anthrax Alexander Fleming penicillin Oswald Avery DNA James Lind scurvy

• p32 Albert Szent-Györgyi vitamin C

• p32 Dr. Oz faith healer Issam Nemeh patient Cathy with worrisome lung CT, miraculously cured "cancer" (but no biopsy), probably infection

• p33 George Bernard Shaw regards Lourdes: "All those canes, braces and crutches, and not a single glass eye, wooden leg, or toupee

• p33 Pamela Miles theraputic touch

• p34 9yo Emily Rosa debunks therapeutic touch, published in JAMA

• p35 John Edward psychic

• p36 James Randi says strategies are hot reading and cold reading

• p37 Oz's superstars of Alternative Medicine, Andrew Weil and Deepak Chopra

• p39 Samuel Hahnemann 1790 homeopathy and Daniel David Palmer 1896 chiropractic manipulation

• p40 Oz offers instruction book for life, personalized ancient wisdom

• p41 "2012" catastrophe movie (2009) promotes "ancient wisdom"

• p41 orthodox medicine constantly changing (learning) while alternative medicine same over hundreds of years
• p42 mainland China only 18% rely in alternative medicines, acupuncture almost solely by the rural poor

• p42 Hippocratic Oaths : Medicine and Its Discontents by Raymond Tallis

• p42 Snake Oil And Other Preoccupations by John Diamond

• p47 Ch 2 The Vitamin Craze: Linus Pauling's Ironic Legacy

• 13 vitamins

• 9 soluble:B₁ thiamine B₂ riboflavin B₃ niacin, nicotinic acid B₄ adenine B₅ pantothenic acid B₆ pyrodoxine B₇ biotin B₈ inositol B₉ folic acid B₁₀ PABA paramonobenzoic acid B₁₁ salicylic acid B₁₂ cobalamin C ascorbic acid

• 4 insoluble:A retinol D calciferol E tocopherol K phylloquinone

• p48 2011 UMinn women taking multivitamins die at higher rates

• p48 2011 Cleveland Clinic men taking vitamin E risk prostate cancer

• p48 Seven previous studies show vitamins risk cancer, heart disease, and shortened lives [Citation needed]
  • are these association or double-blind-trial causal? Perhaps people at higher risk are motivated to take vitamins
• p49-50 Linus Pauling accomplishments

• p51 1966, 65yo Pauling gets letter from biochemist Irwin Stone suggesting 3000mg Vitamin C for longevity

• p52 Vitamin C and the Common Cold

• p53 Vitamins for Prevention of Colds December 19, 1942 DONALD W. COWAN, M.D.; HAROLD S. DIEHL, M.D.; A. B. BAKER, M.D. full paper PDF (19th, not 14th

  • https://en.wikipedia.org/wiki/Daniel_David_Palmer ... vitamin C no effect on colds

• p54 Pauling persisted, attributed cold symptoms to allergies.
• p54 1971 Glasgow Ewan Cameron claimed 10g/d Vitamin C helped cancer patients, but those patients started healthier
• p55 1971 Pauling claimed 10% cancer decrease, in 1977 claimed 75% cancer decrease, someday maximum age 150yo

• p55 1979/Sep Moertel Failure of High-Dose Vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer

• p55 1985/Jan Moertel High-Dose Vitamin C versus Placebo in the Treatment of Patients with Advanced Cancer Who Have Had No Prior Chemotherapy — A Randomized Double-Blind Comparison

  • Fanatic: one who can't change his mind and won't change the subject Esar's Comic Dictionary 1943

• p56 Pauling claims vitamins as cure-all

• p57 April 6 1992 Time article by Anastasia Toufexis

  • Pauling died of prostate cancer August 19, 1994, Pauling and Ava's ashes interred in Oswego Pioneer Cemetery near parents' graves

  • Probably Here Northwest of Stafford Road, entrance on northeast, 5 parking spots on one lane road through cemetery

• p58 1994 Finnish smokers given vitamin E, beta carotine more likely to die of lung cancer or heart disease placebo control

• p59 1996 Asbestos Beta Carotine Retinol placebo control

• p59 2004 Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

• p59 2005 Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality free

• p61 etc. "antioxidant paradox" ... free radicals might also hinder immune reaction to bacteria and cancer cells

• p65 Ch 3 The Supplement Industry Gets a Free Pass: Neutering the FDA

• p66 1906 Pure Food and Drug Act chemist Harvey Washington Wiley

• p67 Samuel Hopkins Adams Colliers The Great American Fraud

• p68 Upton Sinclair

• p69 Pure Food and Drug Act of 1906

• p70 Food, Drug, and Insecticide Administration

• p70 Elixir sulfanilamide 72% Diethylene glycol

• p71 Food, Drug, and Cosmetic Act of 1938 required safety testing, but not effectivenss

• p71 Chemie Grünenthal thalidomide sedative phocomelia and other deformities

• p72 National Health Federation NHF supplement lobbying group founded by Fred Hart, Harry Hoxley, Royal Lee, Kirkpatrick Dilling, Bruce Halstead, Victor Earl Irons

• p75 Rogers-Proxmire Amendment of 1976

• p77 Natural Causes Death, Lies, and Politics in America's Vitamin and Herbal Supplement Industry Dan Hurley 1957-

• p78 1991 Food, Drug, Cosmetic, and Device Enforcement Amendments Henry Waxman and David Kessler

• p83 Dietary Supplement Health and Education Act of 1994

• p88 Merck and Vioxx

• p90 Trick or Treatment? Simon Singh 2009

• p91 1983 to 2004, 1.3 million reports of adverse reactions to supplements, 175K hospitalizations, 139 deaths
• p92 Harris poll public believes:
  • 68% believe manufacturers report side effects,
  • 58% believe herbals require FDA approval
  • 55% believe scientific evidence is required for product claims

• p94 Ch 4 Fifty-One Thousand New Supplements: Which Ones Work?

• p95 James Lind Scurvy

• p95 Clinical Trials 3 phases

• p96 Phase 3 for RotaTeq 70 thousand children, eleven countries, four years, $350M

• p96 NCCAM might test after marketing, useless/harmful results might get published, but no recall or warnings on product

• p97 NCCAM spent $1.6B between 1999 and 2013 (book) on silly studies, now focuses on supplements and pain relief

• p98 Peter Medawar "kindly conspiracy in which everybody has the best intentions" ... "The controlled clinical trial is an attempt to avoid being taken in by this conspiracy of goodwill"

• p99 Steven Novella " ... they often make claims that are not backed by evidence."

• p99 Lancet Neurology 2012 ginko biloba?s&_sf_s=Burzynski+OTA

• p99 St Johns Wort and Depression JAMA 2002

• p100 2007 garlic and cholesterol

• p101 2011 saw palmetto and prostate

• p102 2011 milk thistle and hepatitis

• p103 2006 Glucosamine and/or Chondroitin Sulfate for Painful Knee Osteoarthritis

• p103 2003 Echinacea for colds

• p103 2012 Omega-3 Fatty Acid for Cardiovascular

• p105 Vitamin D Effective Dose 600iu 15 minute sunlight 2xWeek

• p106 Folic acid

• p111 Ch 5 Menopause and Aging: Suzanne Somers Weighs In

• p113 menopause 5 to 8 year process begins with irregular periods by age 45
• p113 Suzanne Somers 7 Dwarves of Menopause: Itchy, Bitchy, Sweaty, Sleepy, Bloated, Forgetful, and All-Dried-Up"

• p115 hormone replacement

• p122 No truth to the Fountain of Youth

• p128 Ch 6 Autism's Pied Piper: Jenny McCarthy's Crusade

• p129 Bernard Rimland

• p129 DAN Defeat Autism Now

• p130-132 18 "causes" of autism with odd treatments

• p133 Ami Clin

• p133 Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism

• p140 Ch 7 Chronic Lyme Disease: The Blumenthal Affair

• p144 Lyme Disease , Ixodes deer ticks

• p144 bacteriologist Willy Bergdorfer Borrelia burgdorferi

• p145 First stage bull's-eye rash, days to weeks
  • If untreated, second stage, spreads to other parts of body, fatigue, swelling, rash, joint pain, 15% meningitis, Bell's palsy, 5% carditis
  • Third stage months later, 10% experience arthritis
  • Resolves faster if treated early, fewer symptoms later, antibiotics for 2 to 4 weeks
• p146 alternate healers claim fourth stage Chronic Lyme disease with way more symptoms

• p147 Under Our Skin grab bag of symptoms and supplements

• p148 Wolf Storl teasel cure (affiliated with planet Mars)

• p149 Rife machine

• p151 A Critical Appraisal of “Chronic Lyme Disease” Feder et al 2007 NEJM

• p153 Infectious Disease Society of America IDSA

• "Statement by IDSA against" actually, a long description of therapies, with a paragraph of "Theraputic modalities not recommended" and 19 more "not recommendeds" scattered through this 46 page "Guidelines" paper. "Statement ... against" is misleading.

• p154 Connecticut Attorney General Richard Blumenthal sues IDSA for violating antitrust laws.

• p157 IDSA forms new and different panel, public hearings, New 2010 Report, Chronic Lyme isn't real

• p159 Science, Politics, and Values: The Politicization of Professional Practice Guidelines

• summarypdf "The scientific process is not democratic — no amount of desire for different results can establish them — and inconsistent findings create true controversy only when their methods are of comparable validity."

• p163 Ch 8 Curing Cancer: Steve Jobs, Shark Cartilage, Coffee Enemas, and More

• p163 NYT article about Steve Jobs pancreatic cancer woowoo, then full tilt science later

• p165 Dynamizer

  • Physicist Robert Millikan said, "They are the kind of devices a ten-year-old would build to fool an eight-year-old."

• p167 Harry Hoxsey "The world is made of two kinds of people - 'dem that takes and them that gets took"

• p168 Andrew Ivy Krebiozen mineral oil and creatine.

• p170 Max Gerson "therapies" fooled Steve Jobs

• p171 Shark Cartilage William Lane (stomach acid destroys cartilage proteins

• p173 Ch 9 Sick Children, Desperate Parents: Stanislaw Burzynski's Urine Cure

• p175 Stanislaw Burzynski antineoplaston therapy

  • urine-derived peptieds, peptide derivatives, and mixtures
  • "Galileo's Lawyer: Courtroom Battles in Alternative Health, Complementary Medicine and Experimental Treatments" Jaffe, Richard (2008)

• p177 Gary Null The Suppression of Cancer Cures" in Penthouse October 1979

• p183 Burzynski Clinic

• p184 1992 'Antineoplastons' An Unproved Cancer Therapy - Saul Green, PhD

• p187 Henry S. Friedman @Duke "no one has shown ... that the therapy works ... incredible ... you can do a cancer study on as few as 30 or 40 patients.

• p187 PLX4032 tested on 32 patients, shrunk all tumors

• Vemurafenib approved by FDA 2011 August 17

• p191 1 year after diagnosis, 2012 June 1 Billie Bainbridge dies

• p192 Burzynski sells supplements and creams. Suzanne Somers promotes them.

• p193 The Emperor of All Maladies: A biography of Cancer by Siddhartha Mukherjee

• p197 Ch 10 Magic Potions in the Twenty-First Century: Rashid Buttar and the Lure of Personality

• p198 Twilight Zone: One for the Angels kwakzalver salesman bargains for a little girl's life

• p203 Rashid Buttarchelation skin ointment for autism

• p205 Desiree Jennings

• p209 chelation mercury amounts the same for autistic and normal children
• p209 mercury damage permanent, even after chelation (to prevent further damage)
• p210 hucksters: "tests not needed, it works because I know it works"
• p211 Buttar chelating cream $150 per small vial
• p212 New Yorker's Michael Specter: "We hate Big Pharma, but we leap into the arms of Big Placebo"

• p214 Chelation also binds to calcium, fatalities

  • August 2003 Oregon 53yo woman chelated by naturopathic physician with 700mg IV EDTA from Creative Compounding Wilsonville OR

• p216 Buttar "swine flu lost its virulence" in Mexico ... 47M infected, 250,000 hospitalized, 12,000 dead including 1,100 children
• p218 brought before North Carolina board, not punished

• p223 Ch 11 The Remarkably Powerful, Highly Underrated Placebo Response

• p226 "Vitamin O": salt water

  • FTC fined manufacturer $375K

• p227 The doctor who fails to have a placebo effect on his patients should be a pathologist" attributed to J. N. Blau

• p230 Rabi Simantov and Solomon Snyder discovered morphine brain receptor

  • Endorphins ( endogenous morphine ) brain peptides stimulate "morphine receptor"

  • naloxone blocks those receptors

  • p231 Ancient Chinese did not believe in dissection, knew nothing about nervous system anatomy, inserted needles randomly

• p233 >86 people died from acupuncture

• p238 oscillococcinum homogenized heart and liver of duck diluted 1e-400

• p239 cough and cold medicines containing pseudoephedrine are dangerous for small children, do little to relieve symptoms.

• p241 Ch 12 When Alternate Medicine Becomes Quackery

.p .p

• p253 Epilogue: Albert Schweitzer and the Witch Doctor: A Parable

• p253 Norman Cousins "Anatomy of an Illness"

• p254 Witch doctor triage
  • minor illness: herbs in a bag with instructions
  • psychological problems: incantations
  • major problems: sent to Dr. Schweitzer