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Modern Virology, Dimmock, 2007
p139 s9.5 Herpesviruses HSV1: 70 genes, 153kbp
α immediate early phase β early γ late
p141: UL41 VHS = virion host shutoff. A ribonuclease that degrades cytoplasmic mRNA that is being translated. Decreases the half-life of all mRNA in the cell, favoring protein expression from viral genes that are being actively transcribed. Later, a more specific host shutoff function (what function???) is expressed, and UL41 is inactivated by binding to VP16.