wiki.keithl.com/DanielGibbs

A Tattoo on my Brain

A Neurologist's Personal Battle against Alzheimer's Disease

Daniel Gibbs with Teresa H. Barker

Cedar Mill Library 616.8311 GIBBS

Also see Dispatches from the land of Alzheimer's 2024

• 2013 age 62 retired due to mild cognitive impairment (born 1951?)

No mention of (causal) pathogens, bacteria, viruses, herpes.

• p24 journalist Greg O'Brien 2014 "On Pluto: inside the Mind of Alzheimer's" - CMill 362.19863 O'Brien 2006

• p27 2007 rose, no smell

• p29
• p34 Brain image of author in 2007, age 56 (b.1951?), pituitary adenoma, radiologist: "slightly more brain atrophy than would be expected at this age.

Cholesterol is mentioned on page 47-48:

"It's not as if the APOE gene is designed for destructive purposes: it's not. The APOE gene is the DNA blueprint for a specific lipoprotein, a protein that is involved in the transport of certain lipids in the blood. It comes in three variants, or alleles: APOE-2, APOE-3, and APOE-4. For reasons that are still not entirely clear, this gene for a protein involved in cholesterol transport also affects risk for acquiring Alzheimer's disease. It seems there is an effect on the proteinAPOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures beta-amyloid in the brain, but the mechanism of APOE-4 risk is probably more complicated. We just don't know yet what it is."

• 1x APOE-2 decreased risk
• 2x APOE-3 0.13x risk
• 1x APOE-4 3.0x risk
• 2x APOE-4 12.0x risk

• Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

• A Possible Role of Apolipoprotein E Polymorphism in Predisposition to Higher Education 2001

• APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

• APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR study

• APOE ε4 and cognitive function in early life: a meta-analysis

• p90 Dr. Yaakov Stern cognitive reserve, resilience to Alzheimer's

• p91 https://doi.org/10.1001/jamanetworkopen.2018.1726 lower early aptitude -> higher odds for Alzheimer's

  • Gibbs expresses this as "more aptitude, lower odds of Alzheimers"
• p95 nuns study: best young adult writers least likely to develop cognitive impairment

• p102 ARIA Amyloid Related Imaging Abnormalities

• p110 Usually read 100 books per year, medical journals, newspapers
• p111 2017 blood pressure 210/110, admitted to ICU for control of severe hypertension
  • not a stroke, but brain swelling and microhemorrhages
• p112 neurologist in San Francisco

• Chapter 14 p127 refs, Aerobic exercise for Alzheimer's

  • WP: 2.5 hours moderate exercise per week
• Refs:

• 1) Total daily physical activity and the risk of AD and cognitive decline in older adults actigraphy ... Mini Mitter acquired by VitalView

• 2) Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults JAMA Neurology 2019

  • PA = pedometer steps per day, mean 5577
  • 150 minutes (2.5 hours) of moderate to vigorous activity per week

• 12) Science 2019 Nov 01 Fultz Bonmassar Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep manuscript

• p200 donepezil Adlarity Aricept 1966

  • rivastigmine Exelon 1997

  • galantamine Razadine

  • memantine = Namenda 2003

• p201 PET scans and spinal taps for biomarkers
• p208 shortness of breath; palpitations or accelerated heart rate

• p222 Ch21ref5: Hyperventilation-induced cerebral ischemia in panic disorder and effect of nimodipine DM Gibbs 1992

  • nimodipine