wiki.keithl.com/DanielGibbs

A Tattoo on my Brain

A Neurologist's Personal Battle against Alzheimer's Disease

Daniel Gibbs with Teresa H. Barker

Cedar Mill Library 616.8311 GIBBS

Also see Dispatches from the land of Alzheimer's 2024

No mention, of pathogens, bacteria, viruses, herpes, as causal.

Cholesterol is mentioned on page 47-48:

"It's not as if the APOE gene is designed for destructive purposes: it's not. The APOE gene is the DNA blueprint for a specific lipoprotein, a protein that is involved in the transport of certain lipids in the blood. It comes in three variants, or alleles: APOE-2, APOE-3, and APOE-4. For reasons that are still not entirely clear, this gene for a protein involved in cholesterol transport also affects risk for acquiring Alzheimer's disease. It seems there is an effect on the protein beta-amyloid in the brain, but the mechanism of APOE-4 risk is probably more complicated. We just don't know yet what it is."

• 1x APOE-2 decreased risk
• 2x APOE-3 0.13x risk
• 1x APOE-4 3.0x risk
• 2x APOE-4 12.0x risk

• Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

• A Possible Role of Apolipoprotein E Polymorphism in Predisposition to Higher Education 2001

• APOE e4 polymorphism in young adults is associated with improved attention and indexed by distinct neural signatures

• APOE ε4 differentially influences change in memory performance depending on age. The SMART-MR study

• APOE ε4 and cognitive function in early life: a meta-analysis