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No mention, of pathogens, bacteria, viruses, herpes, as causal. Cholesterol is mentioned on page 47-48: "It's not as if the APOE gene is designed for destructive purposes: it's not. The APOE gene is the DNA blueprint for a specific lipoprotein, a protein that is involved in the transport of certain lipids in the blood. It comes in three variants, or alleles: APOE-2, APOE-3, and APOE-4. For reasons that are still not entirely clear, this gene for a protein involved in cholesterol transport also affects risk for acquiring Alzheimer's disease. It seems there is an effect on the protein beta-amyloid in the brain, but the mechanism of APOE-4 risk is probably more complicated. We just don't know yet what it is." |
wiki.keithl.com/DanielGibbs
A Tattoo on my Brain
A Neurologist's Personal Battle against Alzheimer's Disease
Daniel Gibbs with Teresa H. Barker
Cedar Mill Library 616.8311 GIBBS
Also see Dispatches from the land of Alzheimer's 2024
- No mention, of pathogens, bacteria, viruses, herpes, as causal. Cholesterol is mentioned on page 47-48:
"It's not as if the APOE gene is designed for destructive purposes: it's not. The APOE gene is the DNA blueprint for a specific lipoprotein, a protein that is involved in the transport of certain lipids in the blood. It comes in three variants, or alleles: APOE-2, APOE-3, and APOE-4. For reasons that are still not entirely clear, this gene for a protein involved in cholesterol transport also affects risk for acquiring Alzheimer's disease. It seems there is an effect on the protein beta-amyloid in the brain, but the mechanism of APOE-4 risk is probably more complicated. We just don't know yet what it is."